Regional Genetics Service

Address

Molecular Genetics Laboratory

Royal Devon & Exeter Foundation NHS Trust

Barrack Road

Exeter

Devon

EX2 5AD

 

Contact 1

 Prof. Sian Ellard

Contact 2

 Dr Carolyn Tysoe

Contact 3

 Mrs Chris Parkes – Administrator

Telephone 1

 +44 (0)1392 402910

Telephone 2

 +44 (0)1392 402946

Fax:

 +44 (0)1392 402946

Email 1

 sian.ellard@rdeft.nhs.uk

Email 2

 carolyn.tysoe@rdeft.nhs.uk

Email 3

 christine.parkes@rdeft.nhs.uk

General email

 moleculargenetics@rdeft.nhs.uk

 

Home page

www.rdehospital.nhs.uk/prof/molecular_genetics/default.htm

 

 

Services offered: 30/04/10 update

Disease

OMIM

UKGTN service*

(Approved, Pending, N/A)

Alagille syndrome (JAG1)

118450

Approved

Alagille syndrome 2; ALGS2 (NOTCH2)

610205

Approved

Aortic valve disease (NOTCH1)

109730

Pending

Bosley-Salih-Alorainy Syndrome; BSAS (HOXA1)

601536

Approved

CADASIL (NOTCH3)

125310

Approved

Carney Complex; CNC (PRKAR1A)

160980

Pending

Charcot Marie Tooth Disease type   2B (LMNA)

605588

Approved 

Chondrodysplasia punctata, Rhizomelic type 1; RCDP1 (PEX7)

215100

Approved

Chondrodysplasia punctata XLD; CDPX2 (EBP)

302960

Approved

Chondrodysplasia punctata XLR;  CDPX1 (ARSE)

302950

Approved

Chondrodysplasia punctata Rhizomelic type 2; RCDP2 (DHAPAT)

222765

Approved

Chondrodysplasia punctata Rhizomelic type 3; RCDP3  (AGPS)

600121

Approved

 

Chimaerism

 

N/A

Congenital Fibrosis of the  Extraocular Muscles type 1; CFEOM1 (KIF21A)

135700

Approved

Congenital fibrosis of the extraocular muscles type 3; CFEOM3 (TUBB3)

600638

Pending

Congenital Generalised Lipodystrophy Type 1 (AGPAT2)

608594

Pending

Congenital Generalised Lipodystrophy Type 2 (BSCL2)

269700

Pending

Cyclin D1 overexpression

 

 N/A

Cystic fibrosis ABCC7 (CFTR)

219700

Approved

Dilated cardio-myopathy type 1a (LMNA)

115200

Approved 

Duane radial ray syndrome; Okihiro syndrome (SALL4)

607323

Approved

Duane retraction syndrome; DRS (CHN1)

604356

Pending

Emery Dreifuss Muscular Dystrophy; EDMD (LMNA)

181350

Approved

Factor V Leiden (FVL)

188055

Approved

Fanconi-Bickel syndrome (SLC2A2)

227810

Approved

Familial Isolated Pituitary Adenoma (AIP)

102200

Approved

Familial medullary thyroid cancer (RET)

155240

Approved

Familial partial lipodystrophy (LMNA)

151660

Approved

Familial  partial lipodystrophy type 3 (PPARG)

604367

Pending

Familial Porencephaly, Hereditary Angiopathy with Nephropathy, Aneurysms and Muscle Cramps (HANAC) syndrome and Brain Small Vessel Disease with Haemorrhage (COL4A1)

175780

611773

607595

Approved

Glucose-Galactose Malabsorption (SLC5A1)

606824

Pending

Haemochromatosis (HFE)

235200

Approved

Hirschsprung disease; HSCR (RET)

142623

Approved

Horizontal gaze palsy with progressive scoliosis; HGPPS (ROBO3)

607313

Approved

Hyperphosphatemic Familial Tumoral Calcinosis (GALNT3)

211900

Approved

Hyperinsulinism dominant (GCK)

602485

Approved

Hyperinsulinism recessive (ABCC8/KCNJ11)

601820

Approved

Hyperinsulinism recessive (HADH)

609975

Approved

Hyperinsulinism-hyperammonemia syndrome (GLUD1)

606762

Approved

Hyperthyroidism (TSHR)

609152

Approved

Hypophosphatemic rickets AD (FGF23)

193100

Approved

Hypophosphatemic rickets XL (PHEX)

307800

Approved

Hypophosphatemic rickets AR ; Type 1 (DMP1)

241520

Approved

Hypophosphatemic rickets AR; Type 2  (ENPP1)

613312

Pending

Hypophosphatemic rickets with hypercalciuria; HHRH (SLC34A3)

241530

Approved

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked; IPEX syndrome (FOXP3)

304790

Approved

Limb Girdle Muscular Dystrophy type 1b; LGMD1B (LMNA)

159001

Approved

Mandibuloacral Dyslasia (ZMPSTE24)

608612

Approved

Maternally inherited diabetes & deafness; MIDD

520000

Approved

Maturity onset diabetes of the young (GCK)

606391

Approved

Maturity onset diabetes of the young (HNF1A)

606391

Approved

Maturity onset diabetes of the young (HNF4A)

606391

Approved

Maturity onset diabetes of the young (IPF1)

606391

Approved

Maturity onset diabetes of the young (NEUROD1)

606391

Approved

Multiple endocrine neoplasia type 1 (MEN1)

131100

Approved

Multiple endocrine neoplasia type 2A; MEN2A (RET)

171400

Approved

Multiple endocrine neoplasia type 2B; MEN2B (RET)

162300

Approved

Multiple endocrine neoplasia type type 4 (CDKN1B)

610755

Pending

Myeloproliferative disorders (JAK2)

147796

Approved

Neonatal diabetes mellitus and congenital hypothyroidism (GLIS3)

610199

Approved

Pancreatic and cerebellar agenesis (PTF1A)

609069

Approved

Permanent neonatal diabetes (KCNJ11)

606176

Approved

Permanent neonatal diabetes (ABCC8)

606176

Approved

Prothrombin (FII)

176930

Approved

Pseudohypoaldosteronism type 2 (WNK4)

145260

Pending

Renal cysts & diabetes (HNF1b)

137920

Approved

Restrictive Dermopathy (ZMPSTE24)

275210

Approved

Spondylocostal Dysostosis type 1; SCD01 (DLL3)

277300

Approved

Spondylocostal Dysostosis type 2 ; SCD02 (MESP2)

608681

Approved

Spondylocostal Dysostosis type 3; SCD03 (LFNG)

609813

Pending

Spondylocostal Dysostosis type 4; SCD04 (HES7)

608059

Pending

Thiamine responsive megaloblastic anaemia TRMA (SLC19A2)

249270

Approved

Wollcott-Rallison syndrome (EIF2AK3)

226980

Approved

B-cell clonality

 

N/A

T-cell clonality

 

N/A

t:(9:22)

 

N/A

t:(11:14)

 

N/A

t:(14:18)

 

N/A

t:(15:17)

 

N/A

IgVh hypermutation

 

N/A

BCR-ABL kinase domain

 

N/A

*Services offered outside main commissioning area geographical

boundaries under the UK specialist Genetic Testing Network - enquire to the laboratory on costs.